EVALUATION OF ANTIULCER POTENTIAL OF ADENOSINE IN INDOMETHACIN INDUCED ULCER IN RATS

• Author Information

  Abdul Yakub Hasmi , Divya Singh

• Divya Singh
• ANTIULCER POTENTIAL OF ADENOSINE

Abstract

This study investigated the anti-ulcer effects of adenosine on indomethacin-induced gastric ulcers in Wistar rats. The rats were divided into six groups: normal control, indomethacin control, indomethacin + lansoprazole (standard treatment), indomethacin + adenosine (100mg/kg), indomethacin + adenosine (150mg/kg), and indomethacin + theophylline. Indomethacin administration significantly increased ulcer score, ulcer index, and levels of malondialdehyde (MDA) and myeloperoxidase (MPO), while decreasing gastric mucus, pH, glutathione (GSH), and superoxide dismutase (SOD) levels. Treatment with both doses of adenosine, as well as the standard treatment lansoprazole, significantly reversed these effects, indicating a protective effect against indomethacin-induced gastric damage. The higher dose of adenosine (150mg/kg) showed greater efficacy compared to the lower dose (100mg/kg). The study concludes that adenosine, by acting on purinergic receptors, exhibits gastroprotective effects and holds potential for treating gastric ulcers. Keywords: Indomethacin, Peptic ulcer, Gastric mucus, Adenosine, etc.