FORMULATION AND EVALUATION OF NIGELLA SATIVA BASED EMULGEL

• Author Information

  Jasneek Kaur Kaloti, Aryan, Rajwant Kaur

• Jasneek Kaur Kaloti, Aryan, Rajwant Kaur
• FORMULATION AND EVALUATION OF NIGELLA SATIVA BASED EMULGEL

Abstract

In addition to meeting basic nutritional requirements, plant-based diets play a pivotal role in enhancing immune function, thereby supporting overall health and providing protection against various diseases. With growing recognition of the link between nutrition and life expectancy, there has been a significant rise in interest surrounding nutraceuticals and functional foods among health-conscious individuals. Nigella sativa (black cumin) seeds have garnered considerable attention due to their diverse range of pharmacological activities, “including anticancer, gastroprotective, cardioprotective, antioxidant, antimicrobial, neuroprotective, antihypertensive, immunomodulatory, antidiabetic, anti-inflammatory, nephroprotective, and liver protective effects”. These therapeutic properties are largely attributed to its diverse phytochemical constituents, such as “thymohydroquinone, thymol, thymoquinone (TQ), carvacrol, α-hederin, nigellidine, and nigellicine.” The present study aimed to develop and evaluate a topical emulgel formulation incorporating Nigella sativa seed extract. The formulation was prepared using the cold process method with Carbopol as the gelling agent. Key parameters such as stability, spreadability, and pH were assessed to determine the suitability of the emulgel for dermal application. The results demonstrated that the prepared formulation exhibited satisfactory physicochemical characteristics, including appropriate pH for topical use, good spreadability, and excellent stability, indicating its potential as a promising herbal topical delivery system.

Research Article