PATHOPHYSIOLOGY AND CONVENTIONAL THERAPEUTIC APPROACHES FOR PEPTIC ULCER: AN OVERVIEW

• Author Information

  Abhishek Godara, Abdul Yakub Hashmi, Yogesh Kumar Sharma 

• Abhishek Godara, Abdul Yakub Hashmi, Yogesh Kumar Sharma 
• PATHOPHYSIOLOGY AND CONVENTIONAL THERAPEUTIC APPROACHES FOR PEPTIC ULCER: AN OVERVIEW

Abstract

Peptic ulcers, characterized by the erosion of the gastrointestinal mucosa, remain a significant clinical challenge worldwide. This overview delves into the intricate pathophysiological mechanisms underlying peptic ulcer development, with a focus on the roles played by Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs (NSAIDs), and gastric acid secretion imbalance. Understanding the multifactorial etiology of peptic ulcers is crucial for devising effective therapeutic strategies. The review further explores conventional therapeutic approaches employed in the management of peptic ulcers. Proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), and mucosal protective agents constitute the cornerstone of pharmacological interventions. The rationale behind their use lies in modulating gastric acid secretion and promoting mucosal healing. Additionally, eradicating H. pylori infection through antibiotic regimens is pivotal in cases where bacterial involvement is identified. This overview synthesizes current knowledge regarding the pathophysiology of peptic ulcers and outlines the conventional therapeutic approaches used in their management. By shedding light on the complexities of this prevalent gastrointestinal disorder, it aims to guide clinicians, researchers, and healthcare practitioners toward more informed decision making and foster the development of innovative and personalized treatment strategies for peptic ulcer.