PHYTOCHEMICAL ANALYSIS AND ANTIDIABETIC POTENTIAL OF Ipomea reniformis in RATS

• Author Information

  Manish Singh Varma, Rakesh Sharma

• Rakesh Sharma
• ANALYSIS AND ANTIDIABETIC POTENTIAL OF Ipomea reniformis

Abstract

Diabetes is a significant global health concern, and India faces a particularly alarming epidemic. This study investigated the antidiabetic potential of Ipomoea reniformis extracts in streptozotocin-induced diabetic rats. Various extracts, including petroleum ether, ethanol, and ethyl acetate fractions, were prepared and subjected to phytochemical analysis. Acute toxicity studies confirmed the safety of the extracts. Diabetic rats treated with ethyl acetate insoluble fractions of ethanolic extracts exhibited significant reductions in blood glucose levels, with the 600 mg/kg dose demonstrating the most potent effect. The extracts also positively impacted serum lipid profiles, improving parameters such as triglycerides, total cholesterol, HDL, LDL, and VLDL. These findings suggest that Ipomoea reniformis, particularly its ethyl acetate insoluble fractions, holds promise as a potential source of antidiabetic agents, warranting further investigation. Keywords: Ipomoea reniformis, Diabetes, HDL, Insulin, LDL, VLDL, etc.